| Customization: | Available |
|---|---|
| CAS No.: | 440122-66-7 |
| Formula: | C13h8brno3 |
|
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| Name | WAY 200070 |
| CAS | 440122-66-7 |
| Purity | 99% |
| Grade Standard | Medicine Grade |
| Sample | WAY 200070 Available |
| COA | WAY 200070 Available |
| Test Method | HPLC |
| Other Name | 4-(7-bromo-5-hydroxy-3H-1,3-benzoxazol-2-ylidene)cyclohexa-2,5-dien-1-one |
| Appearance | White Powder |
| Brand | MT |
| Description | WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM. |
|---|---|
| Related Catalog |
Signaling Pathways >> Others >> Estrogen Receptor/ERR
Research Areas >> Neurological Disease
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| Target |
IC50: 2.3 nM (ERRβ), 155 nM (ERRα)[1] |
| In Vivo | Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect[1]. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected[2]. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator[3]. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test[4]. |
| Animal Admin | Rats: Beginning 1 wk after ovariectomy, animals are given a single daily sc injection of hydroxypropyl betacyclodextran [vehicle; 27% (wt/vol) in saline; DPN (2.0 mg/kg), S-DPN (2.0 mg/kg), R-DPN (2.0 mg/kg), WAY-200070-3 (2.0 mg/kg), or PPT (1.0 mg/kg) in a total volume of 0.2 mL. Three hours after the daily treatment injection on d 4-7, animals undergo behavioral testing[4]. Mice: WAY-200070 is dissolved in a 10% ethanol/90% miglyol solution. WAY-200070 or vehicle is injected subcutaneously at a volume of 10 mL/kg body weight. Male ERβKO, ERαKO (both in C57BL/6 background) and WT C57BL/6 mice are injected with vehicle or WAY-200070 (30 mg/kg s.c.). After 15 min, the animals are sacrificed and the striatum is dissected and quickly frozen in liquid nitrogen and stored at -70°C for subsequent assay[1]. |
| References |
[1]. Hughes ZA, et al. WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent. Neuropharmacology. 2008 Jun;54(7):1136-42. [2]. Clipperton Allen AE, et al. Agonistic behavior in males and females: effects of an estrogen receptor beta agonist in gonadectomized and gonadally intact mice. Psychoneuroendocrinology. 2010 Aug;35(7):1008-22. [3]. Clipperton AE, et al. Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice. Neuropsychopharmacology. 2008 Sep;33(10):2362-75. [4]. Weiser MJ, et al. Estrogen receptor-beta agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress. Endocrinology. 2009 Apr;150(4):1817-25. |
| Molecular Formula | C13H8BrNO3 |
|---|---|
| Molecular Weight | 306.11200 |
| Exact Mass | 304.96900 |
| PSA | 66.49000 |
| LogP | 3.66850 |
| Storage condition | 2-8ºC |
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